Probiotic New Patent Awarded to Zhongke Jiayi - Bifidobacterium bifidum JYBB-163 for Improving Male Semen Quality and Fertility

freeze dried probiotics powder

         Fertility has always been an important research issue in the field of life sciences. In recent years, the incidence of male and female

 infertility has been increasing, with male infertility accounting for about 40% to 50%. The main causes of male infertility include abnormal

 levels of reproductive endocrine hormones, abnormalities in the development of seminal plasmodesmata testes and epididymis, autoimmunity, 

spermatogenesis, and infections, etc., and are mainly manifested in semen quality abnormalities such as oligozoospermia, weak spermatozoa, 

and spermatozoa malformations. Symptoms. Research has found that testosterone level is one of the factors affecting semen quality, testosterone

 is the basic hormone supporting the growth and development of the male reproductive system, low level testosterone is not conducive to the 

growth of the epididymis and other accessory sex glands, thus affecting the maturation of spermatozoa; and testosterone level directly affects 

spermatozoa development, low level testosterone induces spermatogonial apoptosis, which reduces the number of spermatozoa, and directly 

damages spermatozoa DNA; and at the same time low level testosterone At the same time, low level of testosterone will reduce male libido and

 cause erectile dysfunction, which will reduce the degree of satisfaction of the patient's sex life and indirectly affect the patient's semen quality.

freeze dried probiotic powder

   Currently, methods to improve semen quality and fertility include diet and exercise, and medication. Controlling diet and strengthening exercise 

are very low cost, but difficult to adhere to. Medication is quick, but the effect is not long-lasting and has more side effects. Studies have found that 

regulating changes in gut flora can indirectly contribute to the resolution of reproductive disorders. However, the current technology of intestinal 

flora transplantation is still immature, the therapeutic effect is not stable, and there is no report of probiotic treatment with good repeatability.

The present invention isolates a strain of Bifidobacterium bifidum JYBB-163, and makes it into bacterial agent, and it is verified that JYBB-163 

bacterial agent can obviously enhance the testosterone level and testicular coefficient of mice with high-temperature-treated testes, increase 

the total number of sperms and the mobility rate of sperms, and reduce the sperm malformation rate of sperms; and at the same time JYBB -163 

bacteriophage could significantly enhance the testosterone level and testicular coefficient, and improve the plasma membrane integrity, the proportion

 of normal mitochondrial function and DNA integrity in aging rats. Therefore, Bifidobacterium bifidum JYBB-163 bacterial preparation can help to improve

 semen quality and fertility function in men, and can be used to assist in the treatment of male infertility.

Up to now, Zhongke Jiayi has obtained 21 invention patented probiotic, 2 international invention patents, 13 utility model patents, and 5 soft writings.


No.Strain NameStrain No.Collection No.Title of Invention
1Lactobacillus plantarumJYLP-00215801A kind of Lactobacillus plantarum JYLP-002 and its prepared products and applications
2Lactobacillus rhamnosusJYLR-00516103A Lactobacillus rhamnosus JYLR-005 and its hypoglycaemic products and applications
3Lactobacillus plantarumJYLP-32618038A kind of Lactobacillus plantarum JYLP-326 and its application for sleep improvement
4Lactobacillus paracaseiJLPF-17618043Application and products of Lactobacillus paracasei JLPF-176 for the inhibition of Helicobacter pylori infection
5Lactobacillus caseiLC-1221372An allergy-improving Lactobacillus casei LC-12 and its product, application
6Lactobacillus acidophilusJYLA-19121371A Lactobacillus acidophilus JYLA-191 for lowering blood cholesterol level and its application
7Lactobacillus caseiL.Casei2121373A Lactobacillus casei 21 with therapeutic effect on diarrhea and its application
8Bifidobacterium longum JBLC-14118094A Bifidobacterium longum  JBLC-141 capable of eliminating free radicals in the body and its application
9Bifidobacterium longum BLG-1921894Bifidobacterium longum BLG-19 with cellular repair and moisturising effects, applications and products
10Streptococcus thermophilusSTN2622618A Streptococcus thermophilus STN26, bacterial powder and its application in uric acid-lowering products
11Bifidobacterium bifidumBB-2021893A bifidobacterium bifidum BB-20 and the Application in the preparation of products to improve skin texture and reduce pigmentation
12Bifidobacterium LactisJYBR-19018092An application of Bifidobacterium lactis JYBR-190 in the exclusion of heavy metal products from the body
13Lactobacillus caseiJYLC-37418096A kind of Lactobacillus casei JYLC-374 and its application in improving male prostate products
14 Lactobacillus reuteriJYLB-29118041A Lactobacillus reuteri JYLB-291 for amelioration of ulcerative colitis and its application
15Bacillus coagulansBCN01922764A Bacillus coagulans BCN019 with anti-fatigue effect and its bacteriophage and application
16Lactobacillus salivariusJYLS-37218044Application of a kind of Lactobacillus salivarius JYLS-372 in the preparation of alcohol detoxification and liver protection products
17Lactococcus lactis JYLL-6023353A kind of Lactococcus lactis JYLL-60 and its application in the preparation of immunity-enhancing products
18Bifidobacterium LactisJYBR-39018093A Bifidobacterium lactis JYBR-390 with constipation treatment effect and its applications and products
19Bifidobacterium breveJYBF-11724536A kind of Bifidobacterium breve JYBF-117 for relieving dry eye syndrome and its bacteriological preparation and application
20Pediococcus pentosaceusJYPR 933025554Improvement of oral health by Pediococcus pentosaceuss JYPR-9330 and its bacteriophage and application
21Bifidobacterium breveJYBB-16318091A bifidobacterium bifidum JYBB-13 and bacterial preparation, preparation method and application for improving semen quality and fertility in men

In the future, we will continue to pay attention to the protection of intellectual property rights, and will also continue to increase investment in R&D to 

enrich the intellectual property reserves.

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